Comparing ASP, CP, ILP on two Challenging Applications: Wire Routing and Haplotype Inference Elvin Coban Operations Management Tepper School of Business Carnegie Mellon University, USA Esra Erdem Faculty of Engineering and Natural Sciences Sabanci University Ferhan Ture Department of Computer Science University of Maryland, USA We study three declarative programming paradigms, Answer Set Programming (ASP), Constraint Programming (CP), and Integer Linear Programming (ILP), on two challenging applications: wire routing and haplotype inference. We represent these problems in each formalism in a systematic way, compare the formulations both from the point of view of knowledge representation (e.g., how tolerant they are to elaborations) and from the point of view of computational efficiency (in terms of computation time and program size). We discuss possible ways of improving the computational efficiency, and other reformulations of the problems based on different mathematical models.